Phosphoinositide 3-kinase adapter protein 1 (PIK3AP1)
Homo sapiens — UniProt Q6ZUJ8
Data last refreshed: (UniProt release unknown)
Key facts
Phosphoinositide 3-kinase adapter protein 1 (PIK3AP1) is a protein from Homo sapiens identified by UniProt accession Q6ZUJ8, 805 residues long. MolForge cross-references it against 0 known binders and 220 disease associations.
- UniProt accession: Q6ZUJ8; gene symbol PIK3AP1.
- Organism: Homo sapiens.
- Length: 805 amino acids.
- Top disease associations (Open Targets): serum alanine aminotransferase measurement, serum gamma-glutamyl transferase measurement and monocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Phosphoinositide 3-kinase adapter protein 1 |
|---|---|
| UniProt accession | Q6ZUJ8 |
| Gene | PIK3AP1 |
| Organism | Homo sapiens |
| Length | 805 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (220)
Diseases linked to this target (Open Targets).
- serum alanine aminotransferase measurement · score 0.46
- serum gamma-glutamyl transferase measurement · score 0.43
- monocyte count · score 0.41
- aspartate aminotransferase measurement · score 0.40
- monocyte percentage of leukocytes · score 0.40
- neurodegenerative disease · score 0.39
- cancer · score 0.37
- lymphocyte percentage of leukocytes · score 0.30
- lymphocyte count · score 0.30
- glioblastoma multiforme · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZUJ8-F1 | alphafold | PREDICTED | 64.92 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZUJ8.
Amino-acid sequence (805 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PIK3AP1?
The strongest Open Targets associations for PIK3AP1 are serum alanine aminotransferase measurement, serum gamma-glutamyl transferase measurement, monocyte count, aspartate aminotransferase measurement and monocyte percentage of leukocytes.
How long is the PIK3AP1 protein?
The Homo sapiens PIK3AP1 protein (UniProt Q6ZUJ8) is 805 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZUJ8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZUJ8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.