Rho GTPase-activating protein 27 (ARHGAP27)
Homo sapiens — UniProt Q6ZUM4
Data last refreshed: (UniProt release unknown)
Key facts
Rho GTPase-activating protein 27 (ARHGAP27) is a protein from Homo sapiens identified by UniProt accession Q6ZUM4, 889 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.
- UniProt accession: Q6ZUM4; gene symbol ARHGAP27.
- Organism: Homo sapiens.
- Length: 889 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, leukocyte count and systolic blood pressure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Rho GTPase-activating protein 27 |
|---|---|
| UniProt accession | Q6ZUM4 |
| Gene | ARHGAP27 |
| Organism | Homo sapiens |
| Length | 889 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (69)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- leukocyte count · score 0.35
- systolic blood pressure · score 0.29
- neuroticism measurement · score 0.27
- protein measurement · score 0.23
- Red cell distribution width · score 0.23
- intelligence · score 0.20
- total cortical area measurement · score 0.17
- hemoglobin measurement · score 0.17
- childhood onset asthma · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZUM4-F1 | alphafold | PREDICTED | 65.72 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZUM4.
Amino-acid sequence (889 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARHGAP27?
The strongest Open Targets associations for ARHGAP27 are neurodegenerative disease, leukocyte count, systolic blood pressure, neuroticism measurement and protein measurement.
How long is the ARHGAP27 protein?
The Homo sapiens ARHGAP27 protein (UniProt Q6ZUM4) is 889 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZUM4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZUM4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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