DNA-binding protein RFX8 (RFX8)
Homo sapiens — UniProt Q6ZV50
Data last refreshed: (UniProt release unknown)
Key facts
DNA-binding protein RFX8 (RFX8) is a protein from Homo sapiens identified by UniProt accession Q6ZV50, 586 residues long. MolForge cross-references it against 0 known binders and 97 disease associations.
- UniProt accession: Q6ZV50; gene symbol RFX8.
- Organism: Homo sapiens.
- Length: 586 amino acids.
- Top disease associations (Open Targets): serum albumin measurement, total blood protein measurement and monocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DNA-binding protein RFX8 |
|---|---|
| UniProt accession | Q6ZV50 |
| Gene | RFX8 |
| Organism | Homo sapiens |
| Length | 586 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (97)
Diseases linked to this target (Open Targets).
- serum albumin measurement · score 0.38
- total blood protein measurement · score 0.38
- monocyte count · score 0.33
- erythrocyte count · score 0.29
- eosinophil count · score 0.28
- blood protein measurement · score 0.27
- monocyte percentage of leukocytes · score 0.25
- ST2 protein measurement · score 0.19
- Female infertility due to fertilization defect · score 0.09
- azoospermia · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZV50-F1 | alphafold | PREDICTED | 70.26 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZV50.
Amino-acid sequence (586 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RFX8?
The strongest Open Targets associations for RFX8 are serum albumin measurement, total blood protein measurement, monocyte count, erythrocyte count and eosinophil count.
How long is the RFX8 protein?
The Homo sapiens RFX8 protein (UniProt Q6ZV50) is 586 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZV50 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZV50 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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