FYVE, RhoGEF and PH domain-containing protein 6 (FGD6)
Homo sapiens — UniProt Q6ZV73
Data last refreshed: (UniProt release unknown)
Key facts
FYVE, RhoGEF and PH domain-containing protein 6 (FGD6) is a protein from Homo sapiens identified by UniProt accession Q6ZV73, 1430 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.
- UniProt accession: Q6ZV73; gene symbol FGD6.
- Organism: Homo sapiens.
- Length: 1430 amino acids.
- Top disease associations (Open Targets): FEV/FVC ratio, coronary artery disease and aspirin use measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | FYVE, RhoGEF and PH domain-containing protein 6 |
|---|---|
| UniProt accession | Q6ZV73 |
| Gene | FGD6 |
| Organism | Homo sapiens |
| Length | 1430 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (48)
Diseases linked to this target (Open Targets).
- FEV/FVC ratio · score 0.40
- coronary artery disease · score 0.34
- aspirin use measurement · score 0.31
- platelet count · score 0.30
- brain measurement · score 0.30
- angina pectoris · score 0.29
- brain aneurysm · score 0.28
- myocardial infarction · score 0.27
- chronic obstructive pulmonary disease · score 0.25
- longevity · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZV73-F1 | alphafold | PREDICTED | 54.00 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZV73.
Amino-acid sequence (1430 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FGD6?
The strongest Open Targets associations for FGD6 are FEV/FVC ratio, coronary artery disease, aspirin use measurement, platelet count and brain measurement.
How long is the FGD6 protein?
The Homo sapiens FGD6 protein (UniProt Q6ZV73) is 1430 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZV73 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZV73 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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