SH2 domain-containing protein 5 (SH2D5)
Homo sapiens — UniProt Q6ZV89
Data last refreshed: (UniProt release unknown)
Key facts
SH2 domain-containing protein 5 (SH2D5) is a protein from Homo sapiens identified by UniProt accession Q6ZV89, 423 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.
- UniProt accession: Q6ZV89; gene symbol SH2D5.
- Organism: Homo sapiens.
- Length: 423 amino acids.
- Top disease associations (Open Targets): risk-taking behaviour, physical activity measurement and balding measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SH2 domain-containing protein 5 |
|---|---|
| UniProt accession | Q6ZV89 |
| Gene | SH2D5 |
| Organism | Homo sapiens |
| Length | 423 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (48)
Diseases linked to this target (Open Targets).
- risk-taking behaviour · score 0.12
- physical activity measurement · score 0.11
- balding measurement · score 0.11
- body height · score 0.10
- Red cell distribution width · score 0.09
- white matter microstructure measurement · score 0.08
- lung adenocarcinoma · score 0.07
- chronotype measurement · score 0.06
- autosomal recessive spondylocostal dysostosis · score 0.05
- hematocrit · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZV89-F1 | alphafold | PREDICTED | 70.31 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZV89.
Amino-acid sequence (423 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SH2D5?
The strongest Open Targets associations for SH2D5 are risk-taking behaviour, physical activity measurement, balding measurement, body height and Red cell distribution width.
How long is the SH2D5 protein?
The Homo sapiens SH2D5 protein (UniProt Q6ZV89) is 423 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZV89 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZV89 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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