PH domain leucine-rich repeat-containing protein phosphatase 2 (PHLPP2)
Homo sapiens — UniProt Q6ZVD8
Data last refreshed: (UniProt release unknown)
Key facts
PH domain leucine-rich repeat-containing protein phosphatase 2 (PHLPP2) is a protein from Homo sapiens identified by UniProt accession Q6ZVD8, 1323 residues long. MolForge cross-references it against 0 known binders and 129 disease associations.
- UniProt accession: Q6ZVD8; gene symbol PHLPP2.
- Organism: Homo sapiens.
- Length: 1323 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, serum metabolite measurement and alcohol consumption measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | PH domain leucine-rich repeat-containing protein phosphatase 2 |
|---|---|
| UniProt accession | Q6ZVD8 |
| Gene | PHLPP2 |
| Organism | Homo sapiens |
| Length | 1323 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (129)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- serum metabolite measurement · score 0.31
- alcohol consumption measurement · score 0.30
- thyroid gland adenocarcinoma · score 0.29
- breast adenocarcinoma · score 0.28
- ovarian cancer · score 0.28
- glioblastoma multiforme · score 0.28
- mean corpuscular hemoglobin · score 0.27
- mean corpuscular volume · score 0.26
- haptoglobin measurement · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZVD8-F1 | alphafold | PREDICTED | 74.50 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZVD8.
Amino-acid sequence (1323 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PHLPP2?
The strongest Open Targets associations for PHLPP2 are neurodegenerative disease, serum metabolite measurement, alcohol consumption measurement, thyroid gland adenocarcinoma and breast adenocarcinoma.
How long is the PHLPP2 protein?
The Homo sapiens PHLPP2 protein (UniProt Q6ZVD8) is 1323 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZVD8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZVD8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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