Espin-like protein (ESPNL)
Homo sapiens — UniProt Q6ZVH7
Data last refreshed: (UniProt release unknown)
Key facts
Espin-like protein (ESPNL) is a protein from Homo sapiens identified by UniProt accession Q6ZVH7, 1005 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.
- UniProt accession: Q6ZVH7; gene symbol ESPNL.
- Organism: Homo sapiens.
- Length: 1005 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, mathematical ability and protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Espin-like protein |
|---|---|
| UniProt accession | Q6ZVH7 |
| Gene | ESPNL |
| Organism | Homo sapiens |
| Length | 1005 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (53)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.38
- mathematical ability · score 0.15
- protein measurement · score 0.13
- deafness · score 0.11
- eosinophil count · score 0.10
- creatinine measurement · score 0.09
- autosomal recessive nonsyndromic hearing loss 1B · score 0.09
- hearing loss, autosomal recessive · score 0.09
- autosomal dominant nonsyndromic hearing loss 7 · score 0.08
- deafness, aminoglycoside-induced · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZVH7-F1 | alphafold | PREDICTED | 64.66 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZVH7.
Amino-acid sequence (1005 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ESPNL?
The strongest Open Targets associations for ESPNL are neurodegenerative disease, mathematical ability, protein measurement, deafness and eosinophil count.
How long is the ESPNL protein?
The Homo sapiens ESPNL protein (UniProt Q6ZVH7) is 1005 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZVH7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZVH7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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