8-oxo-dGDP phosphatase NUDT18 (NUDT18)
Homo sapiens — UniProt Q6ZVK8
Data last refreshed: (UniProt release unknown)
Key facts
8-oxo-dGDP phosphatase NUDT18 (NUDT18) is a protein from Homo sapiens identified by UniProt accession Q6ZVK8, 323 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.
- UniProt accession: Q6ZVK8; gene symbol NUDT18.
- Organism: Homo sapiens.
- Length: 323 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, body fat percentage and cutaneous melanoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 8-oxo-dGDP phosphatase NUDT18 |
|---|---|
| UniProt accession | Q6ZVK8 |
| Gene | NUDT18 |
| Organism | Homo sapiens |
| Length | 323 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (25)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.19
- body fat percentage · score 0.14
- cutaneous melanoma · score 0.13
- brain measurement · score 0.13
- BMI-adjusted waist-hip ratio · score 0.12
- waist-hip ratio · score 0.11
- nevus count · score 0.11
- frailty measurement · score 0.10
- fat body mass · score 0.10
- serum alanine aminotransferase measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZVK8-F1 | alphafold | PREDICTED | 94.74 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZVK8.
Amino-acid sequence (323 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NUDT18?
The strongest Open Targets associations for NUDT18 are neurodegenerative disease, body fat percentage, cutaneous melanoma, brain measurement and BMI-adjusted waist-hip ratio.
How long is the NUDT18 protein?
The Homo sapiens NUDT18 protein (UniProt Q6ZVK8) is 323 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZVK8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZVK8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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