Hemojuvelin (HJV)
Homo sapiens — UniProt Q6ZVN8
Data last refreshed: (UniProt release unknown)
Key facts
Hemojuvelin (HJV) is a protein from Homo sapiens identified by UniProt accession Q6ZVN8, 426 residues long. MolForge cross-references it against 0 known binders and 172 disease associations.
- UniProt accession: Q6ZVN8; gene symbol HJV.
- Organism: Homo sapiens.
- Length: 426 amino acids.
- Top disease associations (Open Targets): hemochromatosis type 2A, hemochromatosis type 2 and hereditary hemochromatosis type 1.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Hemojuvelin |
|---|---|
| UniProt accession | Q6ZVN8 |
| Gene | HJV |
| Organism | Homo sapiens |
| Length | 426 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (172)
Diseases linked to this target (Open Targets).
- hemochromatosis type 2A · score 0.77
- hemochromatosis type 2 · score 0.53
- hereditary hemochromatosis type 1 · score 0.42
- serum albumin measurement · score 0.18
- hemochromatosis type 5 · score 0.09
- FTH1-related iron overload · score 0.09
- microcytic anemia with liver iron overload · score 0.08
- hepatocellular carcinoma · score 0.08
- cirrhosis of liver · score 0.08
- Adult-onset autosomal recessive sideroblastic anemia · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZVN8-F1 | alphafold | PREDICTED | 81.29 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZVN8.
Amino-acid sequence (426 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HJV?
The strongest Open Targets associations for HJV are hemochromatosis type 2A, hemochromatosis type 2, hereditary hemochromatosis type 1, serum albumin measurement and hemochromatosis type 5.
How long is the HJV protein?
The Homo sapiens HJV protein (UniProt Q6ZVN8) is 426 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZVN8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZVN8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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