Ankyrin repeat and SOCS box protein 18 (ASB18)
Homo sapiens — UniProt Q6ZVZ8
Data last refreshed: (UniProt release unknown)
Key facts
Ankyrin repeat and SOCS box protein 18 (ASB18) is a protein from Homo sapiens identified by UniProt accession Q6ZVZ8, 466 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.
- UniProt accession: Q6ZVZ8; gene symbol ASB18.
- Organism: Homo sapiens.
- Length: 466 amino acids.
- Top disease associations (Open Targets): self reported educational attainment, smoking status measurement and adolescent idiopathic scoliosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ankyrin repeat and SOCS box protein 18 |
|---|---|
| UniProt accession | Q6ZVZ8 |
| Gene | ASB18 |
| Organism | Homo sapiens |
| Length | 466 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (38)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.34
- smoking status measurement · score 0.32
- adolescent idiopathic scoliosis · score 0.24
- schizophrenia · score 0.07
- Crigler-Najjar syndrome type 2 · score 0.06
- maple syrup urine disease · score 0.06
- sarcosinemia · score 0.06
- drug use measurement · score 0.06
- body mass index · score 0.05
- transient familial neonatal hyperbilirubinemia · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZVZ8-F1 | alphafold | PREDICTED | 80.86 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZVZ8.
Amino-acid sequence (466 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ASB18?
The strongest Open Targets associations for ASB18 are self reported educational attainment, smoking status measurement, adolescent idiopathic scoliosis, schizophrenia and Crigler-Najjar syndrome type 2.
How long is the ASB18 protein?
The Homo sapiens ASB18 protein (UniProt Q6ZVZ8) is 466 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZVZ8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZVZ8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.