Rho GTPase-activating protein SYDE1 (SYDE1)
Homo sapiens — UniProt Q6ZW31
Data last refreshed: (UniProt release unknown)
Key facts
Rho GTPase-activating protein SYDE1 (SYDE1) is a protein from Homo sapiens identified by UniProt accession Q6ZW31, 735 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.
- UniProt accession: Q6ZW31; gene symbol SYDE1.
- Organism: Homo sapiens.
- Length: 735 amino acids.
- Top disease associations (Open Targets): age-related macular degeneration, X-linked retinal dysplasia and severe early-childhood-onset retinal dystrophy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Rho GTPase-activating protein SYDE1 |
|---|---|
| UniProt accession | Q6ZW31 |
| Gene | SYDE1 |
| Organism | Homo sapiens |
| Length | 735 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (23)
Diseases linked to this target (Open Targets).
- age-related macular degeneration · score 0.07
- X-linked retinal dysplasia · score 0.06
- severe early-childhood-onset retinal dystrophy · score 0.05
- age related macular degeneration 4 · score 0.05
- age related macular degeneration 7 · score 0.05
- age related macular degeneration 11 · score 0.05
- Familial exudative vitreoretinopathy · score 0.04
- proliferative vitreoretinopathy · score 0.04
- exudative vitreoretinopathy 2, X-linked · score 0.03
- neoplasm · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZW31-F1 | alphafold | PREDICTED | 61.34 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZW31.
Amino-acid sequence (735 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SYDE1?
The strongest Open Targets associations for SYDE1 are age-related macular degeneration, X-linked retinal dysplasia, severe early-childhood-onset retinal dystrophy, age related macular degeneration 4 and age related macular degeneration 7.
How long is the SYDE1 protein?
The Homo sapiens SYDE1 protein (UniProt Q6ZW31) is 735 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZW31 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZW31 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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