PAX-interacting protein 1 (PAXIP1)
Homo sapiens — UniProt Q6ZW49
Data last refreshed: (UniProt release unknown)
Key facts
PAX-interacting protein 1 (PAXIP1) is a protein from Homo sapiens identified by UniProt accession Q6ZW49, 1069 residues long. MolForge cross-references it against 0 known binders and 68 disease associations.
- UniProt accession: Q6ZW49; gene symbol PAXIP1.
- Organism: Homo sapiens.
- Length: 1069 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, breast adenocarcinoma and cognitive function measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | PAX-interacting protein 1 |
|---|---|
| UniProt accession | Q6ZW49 |
| Gene | PAXIP1 |
| Organism | Homo sapiens |
| Length | 1069 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (68)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.38
- breast adenocarcinoma · score 0.26
- cognitive function measurement · score 0.23
- endometrial cancer · score 0.23
- ovarian cancer · score 0.18
- head and neck squamous cell carcinoma · score 0.15
- lung adenocarcinoma · score 0.12
- esophageal cancer · score 0.09
- pulmonary arterial hypertension · score 0.08
- hepatocellular carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZW49-F1 | alphafold | PREDICTED | 69.12 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZW49.
Amino-acid sequence (1069 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PAXIP1?
The strongest Open Targets associations for PAXIP1 are neurodegenerative disease, breast adenocarcinoma, cognitive function measurement, endometrial cancer and ovarian cancer.
How long is the PAXIP1 protein?
The Homo sapiens PAXIP1 protein (UniProt Q6ZW49) is 1069 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZW49 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZW49 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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