Chaperonin-containing T-complex member BBS12 (BBS12)
Homo sapiens — UniProt Q6ZW61
Data last refreshed: (UniProt release unknown)
Key facts
Chaperonin-containing T-complex member BBS12 (BBS12) is a protein from Homo sapiens identified by UniProt accession Q6ZW61, 710 residues long. MolForge cross-references it against 0 known binders and 113 disease associations.
- UniProt accession: Q6ZW61; gene symbol BBS12.
- Organism: Homo sapiens.
- Length: 710 amino acids.
- Top disease associations (Open Targets): Bardet-Biedl syndrome 12, Bardet-Biedl syndrome and Bardet-Biedl syndrome 1.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Chaperonin-containing T-complex member BBS12 |
|---|---|
| UniProt accession | Q6ZW61 |
| Gene | BBS12 |
| Organism | Homo sapiens |
| Length | 710 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (113)
Diseases linked to this target (Open Targets).
- Bardet-Biedl syndrome 12 · score 0.83
- Bardet-Biedl syndrome · score 0.67
- Bardet-Biedl syndrome 1 · score 0.56
- Retinal dystrophy · score 0.51
- Polydactyly · score 0.46
- polydactyly · score 0.46
- Obesity · score 0.37
- ciliopathy · score 0.37
- obesity · score 0.37
- lymphocyte count · score 0.36
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZW61-F1 | alphafold | PREDICTED | 74.01 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZW61.
Amino-acid sequence (710 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BBS12?
The strongest Open Targets associations for BBS12 are Bardet-Biedl syndrome 12, Bardet-Biedl syndrome, Bardet-Biedl syndrome 1, Retinal dystrophy and Polydactyly.
How long is the BBS12 protein?
The Homo sapiens BBS12 protein (UniProt Q6ZW61) is 710 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZW61 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZW61 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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