BTB/POZ domain-containing protein KCTD8 (KCTD8)
Homo sapiens — UniProt Q6ZWB6
Data last refreshed: (UniProt release unknown)
Key facts
BTB/POZ domain-containing protein KCTD8 (KCTD8) is a protein from Homo sapiens identified by UniProt accession Q6ZWB6, 473 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.
- UniProt accession: Q6ZWB6; gene symbol KCTD8.
- Organism: Homo sapiens.
- Length: 473 amino acids.
- Top disease associations (Open Targets): C-reactive protein measurement, body mass index and atopic eczema.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | BTB/POZ domain-containing protein KCTD8 |
|---|---|
| UniProt accession | Q6ZWB6 |
| Gene | KCTD8 |
| Organism | Homo sapiens |
| Length | 473 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (21)
Diseases linked to this target (Open Targets).
- C-reactive protein measurement · score 0.33
- body mass index · score 0.33
- atopic eczema · score 0.32
- sleep duration · score 0.28
- PHF-tau measurement · score 0.28
- type 2 diabetes mellitus · score 0.23
- age at menarche · score 0.23
- protein measurement · score 0.19
- systolic blood pressure · score 0.05
- Abnormality of refraction · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZWB6-F1 | alphafold | PREDICTED | 65.99 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZWB6.
Amino-acid sequence (473 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KCTD8?
The strongest Open Targets associations for KCTD8 are C-reactive protein measurement, body mass index, atopic eczema, sleep duration and PHF-tau measurement.
How long is the KCTD8 protein?
The Homo sapiens KCTD8 protein (UniProt Q6ZWB6) is 473 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZWB6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZWB6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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