Pleckstrin homology domain-containing family M member 3 (PLEKHM3)
Homo sapiens — UniProt Q6ZWE6
Data last refreshed: (UniProt release unknown)
Key facts
Pleckstrin homology domain-containing family M member 3 (PLEKHM3) is a protein from Homo sapiens identified by UniProt accession Q6ZWE6, 761 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.
- UniProt accession: Q6ZWE6; gene symbol PLEKHM3.
- Organism: Homo sapiens.
- Length: 761 amino acids.
- Top disease associations (Open Targets): heel bone mineral density, body height and testosterone measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pleckstrin homology domain-containing family M member 3 |
|---|---|
| UniProt accession | Q6ZWE6 |
| Gene | PLEKHM3 |
| Organism | Homo sapiens |
| Length | 761 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (36)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.43
- body height · score 0.41
- testosterone measurement · score 0.38
- type 2 diabetes mellitus · score 0.35
- HbA1c measurement · score 0.30
- Inguinal hernia · score 0.28
- pancreas fat measurement · score 0.27
- self reported educational attainment · score 0.26
- mathematical ability · score 0.26
- cognitive function measurement · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZWE6-F1 | alphafold | PREDICTED | 64.93 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZWE6.
Amino-acid sequence (761 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLEKHM3?
The strongest Open Targets associations for PLEKHM3 are heel bone mineral density, body height, testosterone measurement, type 2 diabetes mellitus and HbA1c measurement.
How long is the PLEKHM3 protein?
The Homo sapiens PLEKHM3 protein (UniProt Q6ZWE6) is 761 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZWE6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZWE6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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