Regulator of hemoglobinization and erythroid cell expansion protein (RHEX)
Homo sapiens — UniProt Q6ZWK4
Data last refreshed: (UniProt release unknown)
Key facts
Regulator of hemoglobinization and erythroid cell expansion protein (RHEX) is a protein from Homo sapiens identified by UniProt accession Q6ZWK4, 172 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.
- UniProt accession: Q6ZWK4; gene symbol RHEX.
- Organism: Homo sapiens.
- Length: 172 amino acids.
- Top disease associations (Open Targets): neoplasm, non-small cell lung carcinoma and lung adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Regulator of hemoglobinization and erythroid cell expansion protein |
|---|---|
| UniProt accession | Q6ZWK4 |
| Gene | RHEX |
| Organism | Homo sapiens |
| Length | 172 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (17)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.04
- non-small cell lung carcinoma · score 0.04
- lung adenocarcinoma · score 0.02
- ovarian carcinoma · score 0.01
- cancer · score 0.01
- dysplasia · score 0.01
- acute myeloid leukemia · score 0.01
- papillary renal cell carcinoma · score 0.01
- chronic myelogenous leukemia · score 0.00
- uterine leiomyosarcoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZWK4-F1 | alphafold | PREDICTED | 65.76 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZWK4.
Amino-acid sequence (172 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RHEX?
The strongest Open Targets associations for RHEX are neoplasm, non-small cell lung carcinoma, lung adenocarcinoma, ovarian carcinoma and cancer.
How long is the RHEX protein?
The Homo sapiens RHEX protein (UniProt Q6ZWK4) is 172 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZWK4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZWK4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.