Transmembrane protease serine 11F (TMPRSS11F)
Homo sapiens — UniProt Q6ZWK6
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protease serine 11F (TMPRSS11F) is a protein from Homo sapiens identified by UniProt accession Q6ZWK6, 438 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.
- UniProt accession: Q6ZWK6; gene symbol TMPRSS11F.
- Organism: Homo sapiens.
- Length: 438 amino acids.
- Top disease associations (Open Targets): dermatitis herpetiformis, familial, acute myeloid leukemia and low density lipoprotein cholesterol measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protease serine 11F |
|---|---|
| UniProt accession | Q6ZWK6 |
| Gene | TMPRSS11F |
| Organism | Homo sapiens |
| Length | 438 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (17)
Diseases linked to this target (Open Targets).
- dermatitis herpetiformis, familial · score 0.06
- acute myeloid leukemia · score 0.05
- low density lipoprotein cholesterol measurement · score 0.03
- serum metabolite measurement · score 0.03
- non-small cell lung carcinoma · score 0.02
- drug use measurement · score 0.02
- influenza A (H1N1) · score 0.02
- triglyceride measurement · score 0.02
- C-X-C motif chemokine 10 measurement · score 0.02
- chronic myelogenous leukemia · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZWK6-F1 | alphafold | PREDICTED | 87.74 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZWK6.
Amino-acid sequence (438 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMPRSS11F?
The strongest Open Targets associations for TMPRSS11F are dermatitis herpetiformis, familial, acute myeloid leukemia, low density lipoprotein cholesterol measurement, serum metabolite measurement and non-small cell lung carcinoma.
How long is the TMPRSS11F protein?
The Homo sapiens TMPRSS11F protein (UniProt Q6ZWK6) is 438 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZWK6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZWK6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.