Membrane-bound glycerophospholipid…

About Membrane-bound glycerophospholipid O-acyltransferase 2

Membrane-bound glycerophospholipid O-acyltransferase 2 (MBOAT2) is a protein from Homo sapiens identified by UniProt accession Q6ZWT7, 520 residues long. MolForge cross-references it against 0 known binders and 96 disease associations.

Target properties

Protein name	Membrane-bound glycerophospholipid O-acyltransferase 2
UniProt accession	Q6ZWT7
Gene	MBOAT2
Organism	Homo sapiens
Length	520 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (96)

Diseases linked to this target (Open Targets).

calcium measurement · score 0.32
urate measurement · score 0.29
sleep duration · score 0.26
uric acid measurement · score 0.26
stomach disease · score 0.22
atopic eczema · score 0.08
pachyonychia congenita · score 0.08
neoplasm · score 0.08
drug use measurement · score 0.07
lymphocyte count · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6ZWT7-F1	alphafold	PREDICTED	86.01	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZWT7.

Amino-acid sequence (520 residues)

MATTSTTGST LLQPLSNAVQ LPIDQVNFVV CQLFALLAAI WFRTYLHSSK TSSFIRHVVA TLLGLYLALF CFGWYALHFL VQSGISYCIM IIIGVENMHN YCFVFALGYL TVCQVTRVYI FDYGQYSADF SGPMMIITQK ITSLACEIHD GMFRKDEELT SSQRDLAVRR MPSLLEYLSY NCNFMGILAG PLCSYKDYIT FIEGRSYHIT QSGENGKEET QYERTEPSPN TAVVQKLLVC GLSLLFHLTI CTTLPVEYNI DEHFQATASW PTKIIYLYIS LLAARPKYYF AWTLADAINN AAGFGFRGYD ENGAARWDLI SNLRIQQIEM STSFKMFLDN WNIQTALWLK RVCYERTSFS PTIQTFILSA IWHGVYPGYY LTFLTGVLMT LAARAMRNNF RHYFIEPSQL KLFYDVITWI VTQVAISYTV VPFVLLSIKP SLTFYSSWYY CLHILGILVL LLLPVKKTQR RKNTHENIQL SQSKKFDEGE NSLGQNSFST TNNVCNQNQE IASRHSSLKQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Membrane-bound glycerophospholipid O-acyltransferase 2 (MBOAT2)