Protein O-mannosyl-transferase TMTC3 (TMTC3)
Homo sapiens — UniProt Q6ZXV5
Data last refreshed: (UniProt release unknown)
Key facts
Protein O-mannosyl-transferase TMTC3 (TMTC3) is a protein from Homo sapiens identified by UniProt accession Q6ZXV5, 915 residues long. MolForge cross-references it against 0 known binders and 118 disease associations.
- UniProt accession: Q6ZXV5; gene symbol TMTC3.
- Organism: Homo sapiens.
- Length: 915 amino acids.
- Top disease associations (Open Targets): cobblestone lissencephaly, lissencephaly spectrum disorders and Lissencephaly.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein O-mannosyl-transferase TMTC3 |
|---|---|
| UniProt accession | Q6ZXV5 |
| Gene | TMTC3 |
| Organism | Homo sapiens |
| Length | 915 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (118)
Diseases linked to this target (Open Targets).
- cobblestone lissencephaly · score 0.51
- lissencephaly spectrum disorders · score 0.51
- Lissencephaly · score 0.51
- periventricular nodular heterotopia · score 0.37
- hair color · score 0.29
- hair colour measurement · score 0.23
- genetic disorder · score 0.19
- sunburn · score 0.17
- Joubert syndrome 5 · score 0.15
- Meckel syndrome, type 4 · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZXV5-F1 | alphafold | PREDICTED | 87.64 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZXV5.
Amino-acid sequence (915 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMTC3?
The strongest Open Targets associations for TMTC3 are cobblestone lissencephaly, lissencephaly spectrum disorders, Lissencephaly, periventricular nodular heterotopia and hair color.
How long is the TMTC3 protein?
The Homo sapiens TMTC3 protein (UniProt Q6ZXV5) is 915 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZXV5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZXV5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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