General transcription factor IIH subunit 5 (GTF2H5)
Homo sapiens — UniProt Q6ZYL4
Data last refreshed: (UniProt release unknown)
Key facts
General transcription factor IIH subunit 5 (GTF2H5) is a protein from Homo sapiens identified by UniProt accession Q6ZYL4, 71 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.
- UniProt accession: Q6ZYL4; gene symbol GTF2H5.
- Organism: Homo sapiens.
- Length: 71 amino acids.
- Top disease associations (Open Targets): trichothiodystrophy 3, photosensitive, HIV infection and trichothiodystrophy 1, photosensitive.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | General transcription factor IIH subunit 5 |
|---|---|
| UniProt accession | Q6ZYL4 |
| Gene | GTF2H5 |
| Organism | Homo sapiens |
| Length | 71 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (42)
Diseases linked to this target (Open Targets).
- trichothiodystrophy 3, photosensitive · score 0.67
- HIV infection · score 0.59
- trichothiodystrophy 1, photosensitive · score 0.55
- trichothiodystrophy · score 0.37
- neurodegenerative disease · score 0.21
- Delayed myelination · score 0.18
- genetic disorder · score 0.17
- lipoprotein A measurement · score 0.06
- preeclampsia · score 0.04
- age-related hearing impairment · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ZYL4-F1 | alphafold | PREDICTED | 68.94 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ZYL4.
Amino-acid sequence (71 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GTF2H5?
The strongest Open Targets associations for GTF2H5 are trichothiodystrophy 3, photosensitive, HIV infection, trichothiodystrophy 1, photosensitive, trichothiodystrophy and neurodegenerative disease.
How long is the GTF2H5 protein?
The Homo sapiens GTF2H5 protein (UniProt Q6ZYL4) is 71 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ZYL4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ZYL4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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