Ubiquitin carboxyl-terminal hydrolase 53 (USP53)
Homo sapiens — UniProt Q70EK8
Data last refreshed: (UniProt release unknown)
Key facts
Ubiquitin carboxyl-terminal hydrolase 53 (USP53) is a protein from Homo sapiens identified by UniProt accession Q70EK8, 1073 residues long. MolForge cross-references it against 0 known binders and 101 disease associations.
- UniProt accession: Q70EK8; gene symbol USP53.
- Organism: Homo sapiens.
- Length: 1073 amino acids.
- Top disease associations (Open Targets): cholestasis, progressive familial intrahepatic, 7, with or without hearing loss, cholestasis and deafness.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ubiquitin carboxyl-terminal hydrolase 53 |
|---|---|
| UniProt accession | Q70EK8 |
| Gene | USP53 |
| Organism | Homo sapiens |
| Length | 1073 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (101)
Diseases linked to this target (Open Targets).
- cholestasis, progressive familial intrahepatic, 7, with or without hearing loss · score 0.63
- cholestasis · score 0.62
- deafness · score 0.39
- Cholestasis · score 0.38
- appendicular lean mass · score 0.31
- sex hormone-binding globulin measurement · score 0.26
- neutrophil count · score 0.25
- total blood protein measurement · score 0.22
- total cholesterol measurement · score 0.20
- genetic disorder · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q70EK8-F1 | alphafold | PREDICTED | 55.05 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q70EK8.
Amino-acid sequence (1073 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with USP53?
The strongest Open Targets associations for USP53 are cholestasis, progressive familial intrahepatic, 7, with or without hearing loss, cholestasis, deafness, Cholestasis and appendicular lean mass.
How long is the USP53 protein?
The Homo sapiens USP53 protein (UniProt Q70EK8) is 1073 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q70EK8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q70EK8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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