BTB/POZ domain-containing protein KCTD1 (KCTD1)
Homo sapiens — UniProt Q719H9
Data last refreshed: (UniProt release unknown)
Key facts
BTB/POZ domain-containing protein KCTD1 (KCTD1) is a protein from Homo sapiens identified by UniProt accession Q719H9, 257 residues long. MolForge cross-references it against 0 known binders and 217 disease associations.
- UniProt accession: Q719H9; gene symbol KCTD1.
- Organism: Homo sapiens.
- Length: 257 amino acids.
- Top disease associations (Open Targets): scalp-ear-nipple syndrome, neurodegenerative disease and electrocardiography.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | BTB/POZ domain-containing protein KCTD1 |
|---|---|
| UniProt accession | Q719H9 |
| Gene | KCTD1 |
| Organism | Homo sapiens |
| Length | 257 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (217)
Diseases linked to this target (Open Targets).
- scalp-ear-nipple syndrome · score 0.79
- neurodegenerative disease · score 0.52
- electrocardiography · score 0.50
- sudden cardiac arrest · score 0.40
- breast carcinoma · score 0.35
- balding measurement · score 0.32
- urate measurement · score 0.30
- cystatin C measurement · score 0.22
- body mass index · score 0.21
- central corneal thickness · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q719H9-F1 | alphafold | PREDICTED | 87.33 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q719H9.
Amino-acid sequence (257 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KCTD1?
The strongest Open Targets associations for KCTD1 are scalp-ear-nipple syndrome, neurodegenerative disease, electrocardiography, sudden cardiac arrest and breast carcinoma.
How long is the KCTD1 protein?
The Homo sapiens KCTD1 protein (UniProt Q719H9) is 257 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q719H9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q719H9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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