GRB2-associated and regulator of MAPK protein 2 (GAREM2)
Homo sapiens — UniProt Q75VX8
Data last refreshed: (UniProt release unknown)
Key facts
GRB2-associated and regulator of MAPK protein 2 (GAREM2) is a protein from Homo sapiens identified by UniProt accession Q75VX8, 874 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.
- UniProt accession: Q75VX8; gene symbol GAREM2.
- Organism: Homo sapiens.
- Length: 874 amino acids.
- Top disease associations (Open Targets): Red cell distribution width, mean corpuscular hemoglobin concentration and Asperger syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | GRB2-associated and regulator of MAPK protein 2 |
|---|---|
| UniProt accession | Q75VX8 |
| Gene | GAREM2 |
| Organism | Homo sapiens |
| Length | 874 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (26)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.33
- mean corpuscular hemoglobin concentration · score 0.06
- Asperger syndrome · score 0.05
- Frontotemporal dementia · score 0.04
- frontotemporal dementia · score 0.04
- childhood disintegrative disorder · score 0.04
- autism · score 0.04
- Pick disease · score 0.04
- platelet component distribution width · score 0.04
- mean corpuscular hemoglobin · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q75VX8-F1 | alphafold | PREDICTED | 60.31 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q75VX8.
Amino-acid sequence (874 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GAREM2?
The strongest Open Targets associations for GAREM2 are Red cell distribution width, mean corpuscular hemoglobin concentration, Asperger syndrome, Frontotemporal dementia and frontotemporal dementia.
How long is the GAREM2 protein?
The Homo sapiens GAREM2 protein (UniProt Q75VX8) is 874 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q75VX8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q75VX8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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