About GRB2-associated and regulator of MAPK protein 2
GRB2-associated and regulator of MAPK protein 2 (GAREM2) is a protein
from Homo sapiens identified by UniProt accession
Q75VX8, 874 residues long.
MolForge cross-references it against 0 known binders and
26 disease associations.
Target properties
| Protein name | GRB2-associated and regulator of MAPK protein 2 |
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| UniProt accession | Q75VX8 |
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| Gene | GAREM2 |
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| Organism | Homo sapiens |
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| Length | 874 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (26)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.33
- mean corpuscular hemoglobin concentration · score 0.06
- Asperger syndrome · score 0.05
- Frontotemporal dementia · score 0.04
- frontotemporal dementia · score 0.04
- childhood disintegrative disorder · score 0.04
- autism · score 0.04
- Pick disease · score 0.04
- platelet component distribution width · score 0.04
- mean corpuscular hemoglobin · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q75VX8-F1 | alphafold | PREDICTED | 60.31 | — |
Amino-acid sequence (874 residues)
MEKLAAGLAG LRWSMGAFPL DLIVSRCRLP TLACLGPGEY AEGVSERDIL LIHSCRQWTT VTAHTLEEGH YVIGPKIDIP LQYPGKFKLL EQARDVREPV RYFSSVEEVA SVFPDRIFVM EAITFSVKVV SGEFSEDSEV YNFTLHAGDE LTLMGQAEIL CAKTTKERSR FTTLLRKLGR AGALAGVGGG GPASAGAAGG TGGGGARPVK GKMPCLICMN HRTNESLSLP FQCQGRFSTR SPLELQMQEG EHTVRAIIER VRLPVNVLVP SRPPRNPYDL HPVREGHCYK LVSIISKTVV LGLALRREGP APLHFLLLTD TPRFALPQGL LAGDPRVERL VRDSASYCRE RFDPDEYSTA VREAPAELAE DCASPRRARL CLPAPRAPGL ARAPGPLAPA PAGEGDQEYV SPDWAAAPEP AAPPAEIPYE ELWAHQGPEG LVRPPPGLDL ISFGAAGPPR REPEAPPPPV PPKSEAVKEE CRLLNAPPVP PRGGNGSGRL SSSPPVPPRF PKLQPVHSPS SSLSYYSSGL QDGAGSRSGS GSPSPDTYSL YCYPCTWGDC KVGESSSRPA PGPLPSTTQP SQASRALTEP LSGRAASLLG ADTPVKTYHS CPPLFKPSHP QKRFAPFGAL NPFSGPAYPS GPSAALSSGP RTTSGPVATS GPAYSPGPAS PGQAYSAAPP SSCAPSSSSS SEWQEPVLEP FDPFELGQGS SPEPELLRSQ EPRAVGTPGP GPRLSPLGPS KAFEPEGLVL HQVPTPLSPA ALQGPEAGGA LFLTQGRLEG PPASPRDGAT GFGVRDASSW QPPADLSALS LEEVSRSLRF IGLSEDVVSF FARERIDGSI FVQLSEDILA DDFHLTKLQV KKIMQFIKGW RPKI
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