Heme A synthase COX15 (COX15)
Homo sapiens — UniProt Q7KZN9
Data last refreshed: (UniProt release unknown)
Key facts
Heme A synthase COX15 (COX15) is a protein from Homo sapiens identified by UniProt accession Q7KZN9, 410 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.
- UniProt accession: Q7KZN9; gene symbol COX15.
- Organism: Homo sapiens.
- Length: 410 amino acids.
- Top disease associations (Open Targets): Leigh syndrome, fatal infantile encephalocardiomyopathy and mitochondrial complex IV deficiency, nuclear type 22.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Heme A synthase COX15 |
|---|---|
| UniProt accession | Q7KZN9 |
| Gene | COX15 |
| Organism | Homo sapiens |
| Length | 410 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (50)
Diseases linked to this target (Open Targets).
- Leigh syndrome · score 0.65
- fatal infantile encephalocardiomyopathy · score 0.65
- mitochondrial complex IV deficiency, nuclear type 22 · score 0.62
- genetic disorder · score 0.45
- mitochondrial disease · score 0.37
- cytochrome-c oxidase deficiency disease · score 0.37
- neurodegenerative disease · score 0.26
- leigh syndrome due to mitochondrial complex iv deficiency · score 0.17
- cardiomyopathy · score 0.12
- diverticulitis · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7KZN9-F1 | alphafold | PREDICTED | 85.39 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7KZN9.
Amino-acid sequence (410 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with COX15?
The strongest Open Targets associations for COX15 are Leigh syndrome, fatal infantile encephalocardiomyopathy, mitochondrial complex IV deficiency, nuclear type 22, genetic disorder and mitochondrial disease.
How long is the COX15 protein?
The Homo sapiens COX15 protein (UniProt Q7KZN9) is 410 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7KZN9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7KZN9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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