Rho-related GTP-binding protein RhoU (RHOU)
Homo sapiens — UniProt Q7L0Q8
Data last refreshed: (UniProt release unknown)
Key facts
Rho-related GTP-binding protein RhoU (RHOU) is a protein from Homo sapiens identified by UniProt accession Q7L0Q8, 258 residues long. MolForge cross-references it against 0 known binders and 98 disease associations.
- UniProt accession: Q7L0Q8; gene symbol RHOU.
- Organism: Homo sapiens.
- Length: 258 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, basal cell carcinoma and non-melanoma skin carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Rho-related GTP-binding protein RhoU |
|---|---|
| UniProt accession | Q7L0Q8 |
| Gene | RHOU |
| Organism | Homo sapiens |
| Length | 258 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (98)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.44
- basal cell carcinoma · score 0.42
- non-melanoma skin carcinoma · score 0.40
- skin cancer · score 0.38
- cancer · score 0.29
- skin carcinoma · score 0.28
- keratinocyte carcinoma · score 0.28
- chronic lymphocytic leukemia · score 0.20
- head and neck squamous cell carcinoma · score 0.18
- endometrial cancer · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7L0Q8-F1 | alphafold | PREDICTED | 79.85 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7L0Q8.
Amino-acid sequence (258 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RHOU?
The strongest Open Targets associations for RHOU are neurodegenerative disease, basal cell carcinoma, non-melanoma skin carcinoma, skin cancer and cancer.
How long is the RHOU protein?
The Homo sapiens RHOU protein (UniProt Q7L0Q8) is 258 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7L0Q8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7L0Q8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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