RING finger protein 44 (RNF44)
Homo sapiens — UniProt Q7L0R7
Data last refreshed: (UniProt release unknown)
Key facts
RING finger protein 44 (RNF44) is a protein from Homo sapiens identified by UniProt accession Q7L0R7, 432 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.
- UniProt accession: Q7L0R7; gene symbol RNF44.
- Organism: Homo sapiens.
- Length: 432 amino acids.
- Top disease associations (Open Targets): age at menopause, venous thromboembolism and hepatocellular carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | RING finger protein 44 |
|---|---|
| UniProt accession | Q7L0R7 |
| Gene | RNF44 |
| Organism | Homo sapiens |
| Length | 432 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (27)
Diseases linked to this target (Open Targets).
- age at menopause · score 0.37
- venous thromboembolism · score 0.26
- hepatocellular carcinoma · score 0.07
- X-linked retinal dysplasia · score 0.07
- age-related macular degeneration · score 0.07
- Familial exudative vitreoretinopathy · score 0.06
- choroidal dystrophy, central areolar, 1 · score 0.06
- severe early-childhood-onset retinal dystrophy · score 0.05
- neoplasm · score 0.05
- oral squamous cell carcinoma · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7L0R7-F1 | alphafold | PREDICTED | 55.78 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7L0R7.
Amino-acid sequence (432 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RNF44?
The strongest Open Targets associations for RNF44 are age at menopause, venous thromboembolism, hepatocellular carcinoma, X-linked retinal dysplasia and age-related macular degeneration.
How long is the RNF44 protein?
The Homo sapiens RNF44 protein (UniProt Q7L0R7) is 432 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7L0R7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7L0R7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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