tRNA methyltransferase 10 homolog C (TRMT10C)
Homo sapiens — UniProt Q7L0Y3
Data last refreshed: (UniProt release unknown)
Key facts
tRNA methyltransferase 10 homolog C (TRMT10C) is a protein from Homo sapiens identified by UniProt accession Q7L0Y3, 403 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.
- UniProt accession: Q7L0Y3; gene symbol TRMT10C.
- Organism: Homo sapiens.
- Length: 403 amino acids.
- Top disease associations (Open Targets): Combined oxidative phosphorylation defect type 30, neurodegenerative disease and mitochondrial disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | tRNA methyltransferase 10 homolog C |
|---|---|
| UniProt accession | Q7L0Y3 |
| Gene | TRMT10C |
| Organism | Homo sapiens |
| Length | 403 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (49)
Diseases linked to this target (Open Targets).
- Combined oxidative phosphorylation defect type 30 · score 0.72
- neurodegenerative disease · score 0.49
- mitochondrial disease · score 0.46
- eosinophil count · score 0.41
- Alzheimer disease · score 0.35
- Parkinson disease · score 0.34
- lysosomal storage disease · score 0.34
- multiple sclerosis · score 0.34
- eosinophil percentage of leukocytes · score 0.12
- mean corpuscular volume · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7L0Y3-F1 | alphafold | PREDICTED | 78.19 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7L0Y3.
Amino-acid sequence (403 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TRMT10C?
The strongest Open Targets associations for TRMT10C are Combined oxidative phosphorylation defect type 30, neurodegenerative disease, mitochondrial disease, eosinophil count and Alzheimer disease.
How long is the TRMT10C protein?
The Homo sapiens TRMT10C protein (UniProt Q7L0Y3) is 403 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7L0Y3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7L0Y3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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