Synaptic vesicle glycoprotein 2B (SV2B)
Homo sapiens — UniProt Q7L1I2
Data last refreshed: (UniProt release unknown)
Key facts
Synaptic vesicle glycoprotein 2B (SV2B) is a protein from Homo sapiens identified by UniProt accession Q7L1I2, 683 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.
- UniProt accession: Q7L1I2; gene symbol SV2B.
- Organism: Homo sapiens.
- Length: 683 amino acids.
- Top disease associations (Open Targets): botulism, type 2 diabetes mellitus and protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Synaptic vesicle glycoprotein 2B |
|---|---|
| UniProt accession | Q7L1I2 |
| Gene | SV2B |
| Organism | Homo sapiens |
| Length | 683 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (51)
Diseases linked to this target (Open Targets).
- botulism · score 0.58
- type 2 diabetes mellitus · score 0.31
- protein measurement · score 0.16
- prostate carcinoma · score 0.11
- prostate cancer · score 0.11
- Familial prostate cancer · score 0.11
- partial epilepsy · score 0.09
- glioblastoma multiforme · score 0.07
- astrocytoma · score 0.06
- atypical teratoid rhabdoid tumor · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7L1I2-F1 | alphafold | PREDICTED | 81.96 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7L1I2.
Amino-acid sequence (683 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SV2B?
The strongest Open Targets associations for SV2B are botulism, type 2 diabetes mellitus, protein measurement, prostate carcinoma and prostate cancer.
How long is the SV2B protein?
The Homo sapiens SV2B protein (UniProt Q7L1I2) is 683 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7L1I2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7L1I2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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