Cytochrome b5 reductase 4 (CYB5R4)
Homo sapiens — UniProt Q7L1T6
Data last refreshed: (UniProt release unknown)
Key facts
Cytochrome b5 reductase 4 (CYB5R4) is a protein from Homo sapiens identified by UniProt accession Q7L1T6, 521 residues long. MolForge cross-references it against 0 known binders and 82 disease associations.
- UniProt accession: Q7L1T6; gene symbol CYB5R4.
- Organism: Homo sapiens.
- Length: 521 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Parkinson disease and multiple sclerosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cytochrome b5 reductase 4 |
|---|---|
| UniProt accession | Q7L1T6 |
| Gene | CYB5R4 |
| Organism | Homo sapiens |
| Length | 521 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (82)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- Parkinson disease · score 0.37
- multiple sclerosis · score 0.37
- lysosomal storage disease · score 0.37
- Alzheimer disease · score 0.37
- bone density · score 0.33
- urate measurement · score 0.33
- body mass index · score 0.21
- MODY · score 0.06
- obesity due to melanocortin 4 receptor deficiency · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7L1T6-F1 | alphafold | PREDICTED | 86.66 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7L1T6.
Amino-acid sequence (521 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CYB5R4?
The strongest Open Targets associations for CYB5R4 are neurodegenerative disease, Parkinson disease, multiple sclerosis, lysosomal storage disease and Alzheimer disease.
How long is the CYB5R4 protein?
The Homo sapiens CYB5R4 protein (UniProt Q7L1T6) is 521 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7L1T6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7L1T6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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