Volume-regulated anion channel subunit LRRC8D (LRRC8D)
Homo sapiens — UniProt Q7L1W4
Data last refreshed: (UniProt release unknown)
Key facts
Volume-regulated anion channel subunit LRRC8D (LRRC8D) is a protein from Homo sapiens identified by UniProt accession Q7L1W4, 858 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.
- UniProt accession: Q7L1W4; gene symbol LRRC8D.
- Organism: Homo sapiens.
- Length: 858 amino acids.
- Target class: Ion channel.
- Top disease associations (Open Targets): mean platelet volume, neurodegenerative disease and protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Volume-regulated anion channel subunit LRRC8D |
|---|---|
| UniProt accession | Q7L1W4 |
| Gene | LRRC8D |
| Organism | Homo sapiens |
| Length | 858 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Ion channel (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (26)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.48
- neurodegenerative disease · score 0.30
- protein measurement · score 0.13
- mathematical ability · score 0.13
- diastolic blood pressure · score 0.09
- self reported educational attainment · score 0.09
- isolated asymptomatic elevation of creatine phosphokinase · score 0.07
- heel bone mineral density · score 0.06
- body height · score 0.06
- platelet crit · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7L1W4-F1 | alphafold | PREDICTED | 80.77 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7L1W4.
Amino-acid sequence (858 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LRRC8D?
The strongest Open Targets associations for LRRC8D are mean platelet volume, neurodegenerative disease, protein measurement, mathematical ability and diastolic blood pressure.
How long is the LRRC8D protein?
The Homo sapiens LRRC8D protein (UniProt Q7L1W4) is 858 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7L1W4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7L1W4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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