7SK snRNA methylphosphate capping enzyme (MEPCE)
Homo sapiens — UniProt Q7L2J0
Data last refreshed: (UniProt release unknown)
Key facts
7SK snRNA methylphosphate capping enzyme (MEPCE) is a protein from Homo sapiens identified by UniProt accession Q7L2J0, 689 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.
- UniProt accession: Q7L2J0; gene symbol MEPCE.
- Organism: Homo sapiens.
- Length: 689 amino acids.
- Top disease associations (Open Targets): platelet count, platelet component distribution width and heel bone mineral density.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 7SK snRNA methylphosphate capping enzyme |
|---|---|
| UniProt accession | Q7L2J0 |
| Gene | MEPCE |
| Organism | Homo sapiens |
| Length | 689 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (41)
Diseases linked to this target (Open Targets).
- platelet count · score 0.19
- platelet component distribution width · score 0.13
- heel bone mineral density · score 0.12
- platelet crit · score 0.12
- self reported educational attainment · score 0.12
- Neurodevelopmental delay · score 0.12
- monocyte count · score 0.10
- blood protein measurement · score 0.09
- serum albumin measurement · score 0.08
- attention deficit-hyperactivity disorder 8 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7L2J0-F1 | alphafold | PREDICTED | 62.67 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7L2J0.
Amino-acid sequence (689 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MEPCE?
The strongest Open Targets associations for MEPCE are platelet count, platelet component distribution width, heel bone mineral density, platelet crit and self reported educational attainment.
How long is the MEPCE protein?
The Homo sapiens MEPCE protein (UniProt Q7L2J0) is 689 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7L2J0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7L2J0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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