Centromere protein Q (CENPQ)
Homo sapiens — UniProt Q7L2Z9
Data last refreshed: (UniProt release unknown)
Key facts
Centromere protein Q (CENPQ) is a protein from Homo sapiens identified by UniProt accession Q7L2Z9, 268 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.
- UniProt accession: Q7L2Z9; gene symbol CENPQ.
- Organism: Homo sapiens.
- Length: 268 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, mean reticulocyte volume and mean corpuscular volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Centromere protein Q |
|---|---|
| UniProt accession | Q7L2Z9 |
| Gene | CENPQ |
| Organism | Homo sapiens |
| Length | 268 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (30)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- mean reticulocyte volume · score 0.27
- mean corpuscular volume · score 0.26
- aspartate aminotransferase measurement · score 0.18
- Ischemic stroke · score 0.18
- Red cell distribution width · score 0.17
- blood protein measurement · score 0.14
- homocysteine measurement · score 0.12
- vitamin B12 measurement · score 0.10
- hepatocellular carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7L2Z9-F1 | alphafold | PREDICTED | 73.21 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7L2Z9.
Amino-acid sequence (268 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CENPQ?
The strongest Open Targets associations for CENPQ are neurodegenerative disease, mean reticulocyte volume, mean corpuscular volume, aspartate aminotransferase measurement and Ischemic stroke.
How long is the CENPQ protein?
The Homo sapiens CENPQ protein (UniProt Q7L2Z9) is 268 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7L2Z9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7L2Z9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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