Probable proline--tRNA ligase, mitochondrial (PARS2)
Homo sapiens — UniProt Q7L3T8
Data last refreshed: (UniProt release unknown)
Key facts
Probable proline--tRNA ligase, mitochondrial (PARS2) is a protein from Homo sapiens identified by UniProt accession Q7L3T8, 475 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.
- UniProt accession: Q7L3T8; gene symbol PARS2.
- Organism: Homo sapiens.
- Length: 475 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Alpers syndrome and developmental and epileptic encephalopathy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Probable proline--tRNA ligase, mitochondrial |
|---|---|
| UniProt accession | Q7L3T8 |
| Gene | PARS2 |
| Organism | Homo sapiens |
| Length | 475 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (42)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.56
- Alpers syndrome · score 0.51
- developmental and epileptic encephalopathy · score 0.44
- genetic disorder · score 0.38
- undetermined early-onset epileptic encephalopathy · score 0.37
- adolescent idiopathic scoliosis · score 0.21
- mitochondrial disease · score 0.19
- myoepithelial tumor · score 0.11
- colorectal cancer · score 0.08
- colorectal adenoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7L3T8-F1 | alphafold | PREDICTED | 88.20 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7L3T8.
Amino-acid sequence (475 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PARS2?
The strongest Open Targets associations for PARS2 are neurodegenerative disease, Alpers syndrome, developmental and epileptic encephalopathy, genetic disorder and undetermined early-onset epileptic encephalopathy.
How long is the PARS2 protein?
The Homo sapiens PARS2 protein (UniProt Q7L3T8) is 475 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7L3T8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7L3T8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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