Fatty acid 2-hydroxylase (FA2H)
Homo sapiens — UniProt Q7L5A8
Data last refreshed: (UniProt release unknown)
Key facts
Fatty acid 2-hydroxylase (FA2H) is a protein from Homo sapiens identified by UniProt accession Q7L5A8, 372 residues long. MolForge cross-references it against 0 known binders and 200 disease associations.
- UniProt accession: Q7L5A8; gene symbol FA2H.
- Organism: Homo sapiens.
- Length: 372 amino acids.
- Top disease associations (Open Targets): Autosomal recessive spastic paraplegia type 35, hereditary spastic paraplegia 35 and hereditary spastic paraplegia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Fatty acid 2-hydroxylase |
|---|---|
| UniProt accession | Q7L5A8 |
| Gene | FA2H |
| Organism | Homo sapiens |
| Length | 372 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (200)
Diseases linked to this target (Open Targets).
- Autosomal recessive spastic paraplegia type 35 · score 0.81
- hereditary spastic paraplegia 35 · score 0.76
- hereditary spastic paraplegia · score 0.58
- fatty acid hydroxylase-associated neurodegeneration · score 0.56
- Spastic paraplegia · score 0.55
- Dystonia · score 0.46
- neurodegeneration with brain iron accumulation · score 0.46
- genetic disorder · score 0.45
- spastic ataxia · score 0.27
- 2-methylbutyryl-CoA dehydrogenase deficiency · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7L5A8-F1 | alphafold | PREDICTED | 85.10 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7L5A8.
Amino-acid sequence (372 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FA2H?
The strongest Open Targets associations for FA2H are Autosomal recessive spastic paraplegia type 35, hereditary spastic paraplegia 35, hereditary spastic paraplegia, fatty acid hydroxylase-associated neurodegeneration and Spastic paraplegia.
How long is the FA2H protein?
The Homo sapiens FA2H protein (UniProt Q7L5A8) is 372 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7L5A8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7L5A8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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