Lysophosphatidylcholine acyltransferase 2 (LPCAT2)
Homo sapiens — UniProt Q7L5N7
Data last refreshed: (UniProt release unknown)
Key facts
Lysophosphatidylcholine acyltransferase 2 (LPCAT2) is a protein from Homo sapiens identified by UniProt accession Q7L5N7, 544 residues long. MolForge cross-references it against 0 known binders and 91 disease associations.
- UniProt accession: Q7L5N7; gene symbol LPCAT2.
- Organism: Homo sapiens.
- Length: 544 amino acids.
- Top disease associations (Open Targets): Torg-Winchester syndrome, multicentric osteolysis-nodulosis-arthropathy spectrum and hormone measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Lysophosphatidylcholine acyltransferase 2 |
|---|---|
| UniProt accession | Q7L5N7 |
| Gene | LPCAT2 |
| Organism | Homo sapiens |
| Length | 544 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (91)
Diseases linked to this target (Open Targets).
- Torg-Winchester syndrome · score 0.33
- multicentric osteolysis-nodulosis-arthropathy spectrum · score 0.33
- hormone measurement · score 0.23
- thyroxine measurement · score 0.23
- tuberculosis · score 0.21
- glioblastoma multiforme · score 0.18
- heel bone mineral density · score 0.16
- body height · score 0.15
- bone quantitative ultrasound measurement · score 0.14
- age-related hearing impairment · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7L5N7-F1 | alphafold | PREDICTED | 81.60 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7L5N7.
Amino-acid sequence (544 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LPCAT2?
The strongest Open Targets associations for LPCAT2 are Torg-Winchester syndrome, multicentric osteolysis-nodulosis-arthropathy spectrum, hormone measurement, thyroxine measurement and tuberculosis.
How long is the LPCAT2 protein?
The Homo sapiens LPCAT2 protein (UniProt Q7L5N7) is 544 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7L5N7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7L5N7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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