DET1 homolog (DET1)
Homo sapiens — UniProt Q7L5Y6
Data last refreshed: (UniProt release unknown)
Key facts
DET1 homolog (DET1) is a protein from Homo sapiens identified by UniProt accession Q7L5Y6, 550 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.
- UniProt accession: Q7L5Y6; gene symbol DET1.
- Organism: Homo sapiens.
- Length: 550 amino acids.
- Top disease associations (Open Targets): age at menarche, puberty onset measurement and testosterone measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DET1 homolog |
|---|---|
| UniProt accession | Q7L5Y6 |
| Gene | DET1 |
| Organism | Homo sapiens |
| Length | 550 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (39)
Diseases linked to this target (Open Targets).
- age at menarche · score 0.40
- puberty onset measurement · score 0.29
- testosterone measurement · score 0.29
- age at first facial hair · score 0.27
- neurodegenerative disease · score 0.26
- clear cell renal carcinoma · score 0.18
- IGF-1 measurement · score 0.14
- insulin like growth factor measurement · score 0.14
- thyroid stimulating hormone measurement · score 0.14
- hormone measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7L5Y6-F1 | alphafold | PREDICTED | 88.99 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7L5Y6.
Amino-acid sequence (550 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DET1?
The strongest Open Targets associations for DET1 are age at menarche, puberty onset measurement, testosterone measurement, age at first facial hair and neurodegenerative disease.
How long is the DET1 protein?
The Homo sapiens DET1 protein (UniProt Q7L5Y6) is 550 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7L5Y6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7L5Y6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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