E3 ubiquitin-protein transferase MAEA (MAEA)
Homo sapiens — UniProt Q7L5Y9
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein transferase MAEA (MAEA) is a protein from Homo sapiens identified by UniProt accession Q7L5Y9, 396 residues long. MolForge cross-references it against 0 known binders and 175 disease associations.
- UniProt accession: Q7L5Y9; gene symbol MAEA.
- Organism: Homo sapiens.
- Length: 396 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, mean corpuscular hemoglobin and refractive error measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein transferase MAEA |
|---|---|
| UniProt accession | Q7L5Y9 |
| Gene | MAEA |
| Organism | Homo sapiens |
| Length | 396 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (175)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- mean corpuscular hemoglobin · score 0.23
- refractive error measurement · score 0.22
- type 2 diabetes mellitus · score 0.21
- pulse pressure measurement · score 0.13
- chronotype measurement · score 0.07
- hemoglobin D disease · score 0.05
- vital capacity · score 0.05
- hemoglobin E disease · score 0.04
- appendicular lean mass · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7L5Y9-F1 | alphafold | PREDICTED | 91.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7L5Y9.
Amino-acid sequence (396 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MAEA?
The strongest Open Targets associations for MAEA are neurodegenerative disease, mean corpuscular hemoglobin, refractive error measurement, type 2 diabetes mellitus and pulse pressure measurement.
How long is the MAEA protein?
The Homo sapiens MAEA protein (UniProt Q7L5Y9) is 396 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7L5Y9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7L5Y9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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