Diphthine--ammonia ligase (DPH6)
Homo sapiens — UniProt Q7L8W6
Data last refreshed: (UniProt release unknown)
Key facts
Diphthine--ammonia ligase (DPH6) is a protein from Homo sapiens identified by UniProt accession Q7L8W6, 267 residues long. MolForge cross-references it against 0 known binders and 198 disease associations.
- UniProt accession: Q7L8W6; gene symbol DPH6.
- Organism: Homo sapiens.
- Length: 267 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, body mass index and mathematical ability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Diphthine--ammonia ligase |
|---|---|
| UniProt accession | Q7L8W6 |
| Gene | DPH6 |
| Organism | Homo sapiens |
| Length | 267 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (198)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.51
- body mass index · score 0.39
- mathematical ability · score 0.26
- diet measurement · score 0.22
- restless legs syndrome · score 0.21
- sex hormone-binding globulin measurement · score 0.20
- neuroticism measurement · score 0.18
- wellbeing measurement · score 0.18
- depressive symptom measurement · score 0.18
- BMI-adjusted waist-hip ratio · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7L8W6-F1 | alphafold | PREDICTED | 90.03 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7L8W6.
Amino-acid sequence (267 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DPH6?
The strongest Open Targets associations for DPH6 are neurodegenerative disease, body mass index, mathematical ability, diet measurement and restless legs syndrome.
How long is the DPH6 protein?
The Homo sapiens DPH6 protein (UniProt Q7L8W6) is 267 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7L8W6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7L8W6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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