SH2 domain-containing adapter protein F (SHF)
Homo sapiens — UniProt Q7M4L6
Data last refreshed: (UniProt release unknown)
Key facts
SH2 domain-containing adapter protein F (SHF) is a protein from Homo sapiens identified by UniProt accession Q7M4L6, 423 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.
- UniProt accession: Q7M4L6; gene symbol SHF.
- Organism: Homo sapiens.
- Length: 423 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, cortical thickness and urinary metabolite measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SH2 domain-containing adapter protein F |
|---|---|
| UniProt accession | Q7M4L6 |
| Gene | SHF |
| Organism | Homo sapiens |
| Length | 423 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (29)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- cortical thickness · score 0.24
- urinary metabolite measurement · score 0.22
- brain measurement · score 0.16
- glioblastoma multiforme · score 0.07
- creatinine measurement · score 0.05
- neoplasm · score 0.04
- neuroblastoma · score 0.02
- drug use measurement · score 0.02
- congenital heart disease · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7M4L6-F1 | alphafold | PREDICTED | 62.60 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7M4L6.
Amino-acid sequence (423 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SHF?
The strongest Open Targets associations for SHF are neurodegenerative disease, cortical thickness, urinary metabolite measurement, brain measurement and glioblastoma multiforme.
How long is the SHF protein?
The Homo sapiens SHF protein (UniProt Q7M4L6) is 423 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7M4L6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7M4L6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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