Small integral membrane protein 15 (SMIM15)

About Small integral membrane protein 15

Small integral membrane protein 15 (SMIM15) is a protein from Homo sapiens identified by UniProt accession Q7Z3B0, 74 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.

Target properties

Protein name	Small integral membrane protein 15
UniProt accession	Q7Z3B0
Gene	SMIM15
Organism	Homo sapiens
Length	74 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (41)

Diseases linked to this target (Open Targets).

schizophrenia · score 0.33
neurodegenerative disease · score 0.31
health study participation · score 0.30
self reported educational attainment · score 0.28
cortical surface area measurement · score 0.26
attention deficit hyperactivity disorder · score 0.22
neuroimaging measurement · score 0.15
cortical thickness · score 0.15
intelligence · score 0.15
platelet count · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q7Z3B0-F1	alphafold	PREDICTED	94.12	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z3B0.

Amino-acid sequence (74 residues)

MFDIKAWAEY VVEWAAKDPY GFLTTVILAL TPLFLASAVL SWKLAKMIEA REKEQKKKQK RQENIAKAKR LKKD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards