Neuronal growth regulator 1 (NEGR1)
Homo sapiens — UniProt Q7Z3B1
Data last refreshed: (UniProt release unknown)
Key facts
Neuronal growth regulator 1 (NEGR1) is a protein from Homo sapiens identified by UniProt accession Q7Z3B1, 354 residues long. MolForge cross-references it against 0 known binders and 150 disease associations.
- UniProt accession: Q7Z3B1; gene symbol NEGR1.
- Organism: Homo sapiens.
- Length: 354 amino acids.
- Top disease associations (Open Targets): self reported educational attainment, body mass index and unipolar depression.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Neuronal growth regulator 1 |
|---|---|
| UniProt accession | Q7Z3B1 |
| Gene | NEGR1 |
| Organism | Homo sapiens |
| Length | 354 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (150)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.50
- body mass index · score 0.50
- unipolar depression · score 0.49
- intelligence · score 0.48
- diet measurement · score 0.48
- cognitive function measurement · score 0.47
- insomnia measurement · score 0.46
- mathematical ability · score 0.46
- physical activity measurement · score 0.45
- alcohol consumption measurement · score 0.44
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z3B1-F1 | alphafold | PREDICTED | 81.64 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z3B1.
Amino-acid sequence (354 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NEGR1?
The strongest Open Targets associations for NEGR1 are self reported educational attainment, body mass index, unipolar depression, intelligence and diet measurement.
How long is the NEGR1 protein?
The Homo sapiens NEGR1 protein (UniProt Q7Z3B1) is 354 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z3B1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z3B1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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