Nucleoporin p54 (NUP54)
Homo sapiens — UniProt Q7Z3B4
Data last refreshed: (UniProt release unknown)
Key facts
Nucleoporin p54 (NUP54) is a protein from Homo sapiens identified by UniProt accession Q7Z3B4, 507 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.
- UniProt accession: Q7Z3B4; gene symbol NUP54.
- Organism: Homo sapiens.
- Length: 507 amino acids.
- Top disease associations (Open Targets): dystonia 37, early-onset, with striatal lesions, influenza and HIV infection.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nucleoporin p54 |
|---|---|
| UniProt accession | Q7Z3B4 |
| Gene | NUP54 |
| Organism | Homo sapiens |
| Length | 507 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (45)
Diseases linked to this target (Open Targets).
- dystonia 37, early-onset, with striatal lesions · score 0.55
- influenza · score 0.54
- HIV infection · score 0.54
- viral disease · score 0.53
- neurodegenerative disease · score 0.37
- Histiocytosis · score 0.37
- COVID-19 · score 0.37
- familial infantile bilateral striatal necrosis · score 0.37
- breast adenocarcinoma · score 0.25
- ovarian cancer · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z3B4-F1 | alphafold | PREDICTED | 76.43 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z3B4.
Amino-acid sequence (507 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NUP54?
The strongest Open Targets associations for NUP54 are dystonia 37, early-onset, with striatal lesions, influenza, HIV infection, viral disease and neurodegenerative disease.
How long is the NUP54 protein?
The Homo sapiens NUP54 protein (UniProt Q7Z3B4) is 507 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z3B4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z3B4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.