D-glutamate cyclase, mitochondrial (DGLUCY)
Homo sapiens — UniProt Q7Z3D6
Data last refreshed: (UniProt release unknown)
Key facts
D-glutamate cyclase, mitochondrial (DGLUCY) is a protein from Homo sapiens identified by UniProt accession Q7Z3D6, 616 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.
- UniProt accession: Q7Z3D6; gene symbol DGLUCY.
- Organism: Homo sapiens.
- Length: 616 amino acids.
- Top disease associations (Open Targets): BMI-adjusted waist-hip ratio, waist-hip ratio and BMI-adjusted waist circumference.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | D-glutamate cyclase, mitochondrial |
|---|---|
| UniProt accession | Q7Z3D6 |
| Gene | DGLUCY |
| Organism | Homo sapiens |
| Length | 616 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (47)
Diseases linked to this target (Open Targets).
- BMI-adjusted waist-hip ratio · score 0.34
- waist-hip ratio · score 0.33
- BMI-adjusted waist circumference · score 0.31
- urinary metabolite measurement · score 0.28
- resting heart rate · score 0.27
- diet measurement · score 0.27
- serum alanine aminotransferase measurement · score 0.26
- appendicular lean mass · score 0.25
- aspartate aminotransferase measurement · score 0.21
- age-related hearing impairment · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z3D6-F1 | alphafold | PREDICTED | 86.55 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z3D6.
Amino-acid sequence (616 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DGLUCY?
The strongest Open Targets associations for DGLUCY are BMI-adjusted waist-hip ratio, waist-hip ratio, BMI-adjusted waist circumference, urinary metabolite measurement and resting heart rate.
How long is the DGLUCY protein?
The Homo sapiens DGLUCY protein (UniProt Q7Z3D6) is 616 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z3D6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z3D6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.