Protein mono-ADP-ribosyltransferase TIPARP (TIPARP)
Homo sapiens — UniProt Q7Z3E1
Data last refreshed: (UniProt release unknown)
Key facts
Protein mono-ADP-ribosyltransferase TIPARP (TIPARP) is a protein from Homo sapiens identified by UniProt accession Q7Z3E1, 657 residues long. MolForge cross-references it against 0 known binders and 268 disease associations.
- UniProt accession: Q7Z3E1; gene symbol TIPARP.
- Organism: Homo sapiens.
- Length: 657 amino acids.
- Top disease associations (Open Targets): body mass index, neurodegenerative disease and ovarian carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein mono-ADP-ribosyltransferase TIPARP |
|---|---|
| UniProt accession | Q7Z3E1 |
| Gene | TIPARP |
| Organism | Homo sapiens |
| Length | 657 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (268)
Diseases linked to this target (Open Targets).
- body mass index · score 0.39
- neurodegenerative disease · score 0.38
- ovarian carcinoma · score 0.36
- FEV/FVC ratio · score 0.33
- ovarian serous carcinoma · score 0.32
- body height · score 0.30
- childhood onset asthma · score 0.29
- age at menopause · score 0.29
- chronotype measurement · score 0.26
- malignant epithelial tumor of ovary · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z3E1-F1 | alphafold | PREDICTED | 68.69 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z3E1.
Amino-acid sequence (657 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TIPARP?
The strongest Open Targets associations for TIPARP are body mass index, neurodegenerative disease, ovarian carcinoma, FEV/FVC ratio and ovarian serous carcinoma.
How long is the TIPARP protein?
The Homo sapiens TIPARP protein (UniProt Q7Z3E1) is 657 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z3E1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z3E1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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