About Coiled-coil domain-containing protein 186
Coiled-coil domain-containing protein 186 (CCDC186) is a protein
from Homo sapiens identified by UniProt accession
Q7Z3E2, 898 residues long.
MolForge cross-references it against 0 known binders and
59 disease associations.
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
Disease associations (59)
Diseases linked to this target (Open Targets).
- lean body mass · score 0.37
- Failure to thrive · score 0.34
- Seizure · score 0.34
- Relative macrocephaly · score 0.34
- hypothyroidism · score 0.34
- Microcephaly · score 0.34
- pulmonary valve stenosis · score 0.34
- Growth delay · score 0.34
- EEG with spike-wave complexes · score 0.34
- Severe global developmental delay · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Experimental structures are not indexed in MolForge yet —
search RCSB PDB for Q7Z3E2.
Amino-acid sequence (898 residues)
MSETDHIAST SSDKNVGKTP ELKEDSCNLF SGNESSKLEN ESKLLSLNTD KTLCQPNEHN NRIEAQENYI PDHGGGEDSC AKTDTGSENS EQIANFPSGN FAKHISKTNE TEQKVTQILV ELRSSTFPES ANEKTYSESP YDTDCTKKFI SKIKSVSASE DLLEEIESEL LSTEFAEHRV PNGMNKGEHA LVLFEKCVQD KYLQQEHIIK KLIKENKKHQ ELFVDICSEK DNLREELKKR TETEKQHMNT IKQLESRIEE LNKEVKASRD QLIAQDVTAK NAVQQLHKEM AQRMEQANKK CEEARQEKEA MVMKYVRGEK ESLDLRKEKE TLEKKLRDAN KELEKNTNKI KQLSQEKGRL HQLYETKEGE TTRLIREIDK LKEDINSHVI KVKWAQNKLK AEMDSHKETK DKLKETTTKL TQAKEEADQI RKNCQDMIKT YQESEEIKSN ELDAKLRVTK GELEKQMQEK SDQLEMHHAK IKELEDLKRT FKEGMDELRT LRTKVKCLED ERLRTEDELS KYKEIINRQK AEIQNLLDKV KTADQLQEQL QRGKQEIENL KEEVESLNSL INDLQKDIEG SRKRESELLL FTERLTSKNA QLQSESNSLQ SQFDKVSCSE SQLQSQCEQM KQTNINLESR LLKEEELRKE EVQTLQAELA CRQTEVKALS TQVEELKDEL VTQRRKHASS IKDLTKQLQQ ARRKLDQVES GSYDKEVSSM GSRSSSSGSL NARSSAEDRS PENTGSSVAV DNFPQVDKAM LIERIVRLQK AHARKNEKIE FMEDHIKQLV EEIRKKTKII QSYILREESG TLSSEASDFN KVHLSRRGGI MASLYTSHPA DNGLTLELSL EINRKLQAVL EDTLLKNITL KENLQTLGTE IERLIKHQHE LEQRTKKT
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