Prickle-like protein 2 (PRICKLE2)
Homo sapiens — UniProt Q7Z3G6
Data last refreshed: (UniProt release unknown)
Key facts
Prickle-like protein 2 (PRICKLE2) is a protein from Homo sapiens identified by UniProt accession Q7Z3G6, 844 residues long. MolForge cross-references it against 0 known binders and 77 disease associations.
- UniProt accession: Q7Z3G6; gene symbol PRICKLE2.
- Organism: Homo sapiens.
- Length: 844 amino acids.
- Top disease associations (Open Targets): sensory ataxic neuropathy, dysarthria, and ophthalmoparesis, vital capacity and self reported educational attainment.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Prickle-like protein 2 |
|---|---|
| UniProt accession | Q7Z3G6 |
| Gene | PRICKLE2 |
| Organism | Homo sapiens |
| Length | 844 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (77)
Diseases linked to this target (Open Targets).
- sensory ataxic neuropathy, dysarthria, and ophthalmoparesis · score 0.47
- vital capacity · score 0.43
- self reported educational attainment · score 0.42
- autosomal dominant non-syndromic intellectual disability · score 0.40
- forced expiratory volume · score 0.39
- Global developmental delay · score 0.37
- Neurodevelopmental disorder · score 0.37
- smoking status measurement · score 0.37
- peak expiratory flow · score 0.36
- Sensory ataxic neuropathy - dysarthria - ophthalmoparesis · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z3G6-F1 | alphafold | PREDICTED | 56.33 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z3G6.
Amino-acid sequence (844 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PRICKLE2?
The strongest Open Targets associations for PRICKLE2 are sensory ataxic neuropathy, dysarthria, and ophthalmoparesis, vital capacity, self reported educational attainment, autosomal dominant non-syndromic intellectual disability and forced expiratory volume.
How long is the PRICKLE2 protein?
The Homo sapiens PRICKLE2 protein (UniProt Q7Z3G6) is 844 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z3G6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z3G6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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