Sterile alpha motif domain-containing protein 7 (SAMD7)
Homo sapiens — UniProt Q7Z3H4
Data last refreshed: (UniProt release unknown)
Key facts
Sterile alpha motif domain-containing protein 7 (SAMD7) is a protein from Homo sapiens identified by UniProt accession Q7Z3H4, 446 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.
- UniProt accession: Q7Z3H4; gene symbol SAMD7.
- Organism: Homo sapiens.
- Length: 446 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, macular dystrophy, retinal and sclerosing cholangitis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sterile alpha motif domain-containing protein 7 |
|---|---|
| UniProt accession | Q7Z3H4 |
| Gene | SAMD7 |
| Organism | Homo sapiens |
| Length | 446 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (46)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.24
- macular dystrophy, retinal · score 0.18
- sclerosing cholangitis · score 0.14
- retinitis pigmentosa · score 0.11
- X-linked retinal dysplasia · score 0.10
- age-related macular degeneration · score 0.09
- platelet crit · score 0.08
- severe early-childhood-onset retinal dystrophy · score 0.08
- Familial exudative vitreoretinopathy · score 0.08
- Progressive cone dystrophy · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z3H4-F1 | alphafold | PREDICTED | 55.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z3H4.
Amino-acid sequence (446 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SAMD7?
The strongest Open Targets associations for SAMD7 are neurodegenerative disease, macular dystrophy, retinal, sclerosing cholangitis, retinitis pigmentosa and X-linked retinal dysplasia.
How long is the SAMD7 protein?
The Homo sapiens SAMD7 protein (UniProt Q7Z3H4) is 446 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z3H4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z3H4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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