VPS35 endosomal protein-sorting factor-like (VPS35L)
Homo sapiens — UniProt Q7Z3J2
Data last refreshed: (UniProt release unknown)
Key facts
VPS35 endosomal protein-sorting factor-like (VPS35L) is a protein from Homo sapiens identified by UniProt accession Q7Z3J2, 963 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.
- UniProt accession: Q7Z3J2; gene symbol VPS35L.
- Organism: Homo sapiens.
- Length: 963 amino acids.
- Top disease associations (Open Targets): 3C syndrome, cortical surface area measurement and chickenpox.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | VPS35 endosomal protein-sorting factor-like |
|---|---|
| UniProt accession | Q7Z3J2 |
| Gene | VPS35L |
| Organism | Homo sapiens |
| Length | 963 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (22)
Diseases linked to this target (Open Targets).
- 3C syndrome · score 0.59
- cortical surface area measurement · score 0.22
- chickenpox · score 0.07
- platelet crit · score 0.05
- waist circumference · score 0.04
- platelet count · score 0.03
- late-onset Alzheimers disease · score 0.03
- body mass index · score 0.03
- metabolite measurement · score 0.03
- colorectal cancer · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z3J2-F1 | alphafold | PREDICTED | 84.78 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z3J2.
Amino-acid sequence (963 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with VPS35L?
The strongest Open Targets associations for VPS35L are 3C syndrome, cortical surface area measurement, chickenpox, platelet crit and waist circumference.
How long is the VPS35L protein?
The Homo sapiens VPS35L protein (UniProt Q7Z3J2) is 963 amino acids long.
Browse: Targets: V · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z3J2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z3J2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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