RanBP2-like and GRIP domain-containing protein 4 (RGPD4)

Homo sapiens — UniProt Q7Z3J3

Gene: RGPD4Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

RanBP2-like and GRIP domain-containing protein 4 (RGPD4) is a protein from Homo sapiens identified by UniProt accession Q7Z3J3, 1758 residues long. MolForge cross-references it against 0 known binders and 65 disease associations.

UniProt accession: Q7Z3J3; gene symbol RGPD4.
Organism: Homo sapiens.
Length: 1758 amino acids.
Top disease associations (Open Targets): isolated congenital hypogonadotropic hypogonadism, Testicular regression syndrome and 46,XY complete gonadal dysgenesis.
3D structure: AlphaFold model available.

Target properties

Protein name	RanBP2-like and GRIP domain-containing protein 4
UniProt accession	Q7Z3J3
Gene	RGPD4
Organism	Homo sapiens
Length	1758 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (65)

Diseases linked to this target (Open Targets).

isolated congenital hypogonadotropic hypogonadism · score 0.06
Testicular regression syndrome · score 0.06
46,XY complete gonadal dysgenesis · score 0.06
46,XX testicular disorder of sex development · score 0.06
systemic scleroderma · score 0.06
azoospermia · score 0.06
46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency · score 0.06
myofibromatosis, infantile, 1 · score 0.06
BAP1-related tumor predisposition syndrome · score 0.06
tumor predisposition syndrome 2 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q7Z3J3-F1	alphafold	PREDICTED	66.39	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z3J3.

Amino-acid sequence (1758 residues)

MSCSKAYGER YVASVQGSAP SPRKKSTRGF YFAKLYYEAK EYDLAKKYIC TYINVREMDP RAHRFLGLLY ELEENTEKAV ECYRRSVELN PTQKDLVLKI AELLCKNDVT DGRAKYWVER AAKLFPGSPA IYKLKEQLLD CEGEDGWNKL FDLIQSELYV RPDDVHVNIR LVELYRSTKR LKDAVARCHE AERNIALRSS LEWNSCVVQT LKEYLESLQC LESDKSDWRA TNTDLLLAYA NLMLLTLSTR DVQESRELLE SFDSALQSAK SSLGGNDELS ATFLEMKGHF YMHAGSLLLK MGQHGNNVQW RALSELAALC YLIAFQVPRP KIKLIKGEAG QNLLEMMACD RLSQSGHMLL NLSRGKQDFL KVVVETFANK SGQSALYDAL FSSQSPKDTS FLGSDDIGNI DVQEPELEDL ARYDVGAIRA HNGSLQHLTW LGLQWNSLPA LPGIRKWLKQ LFHHLPQETS RLETNAPESI CILDLEVFLL GVVYTSHLQL KEKCNSHHSS YQPLCLPLPV CKQLCTERQK SWWDAVCTLI HRKAVPGNSA KLRLLVQHEI NTLRAQEKHG LQPALLVHWA KCLQKMGSGL NSFYDQREYI GRSVHYWKKV LPLLKIIKKK NSIPEPIDPL FKHFHSVDIQ ASEIVEYEED AHVTFAILDA VNGNIEDAMT AFESIKSVVS YWNLALIFHR KAEDIANDAL SPEEQEECKN YLRKTRGYLI KILDDSDSNL SVVKKLPVPL ESVKEMLKSV MQELENYSEG DPLYKNGSLR NADSEIKHST PSPTKYSLSP SKSYKYSPKT PPRWAEDQNS LLKMIRQEVK AIKEEMQELK LNSSKSASHH RWPTENYGPD SVPDGYQGSQ TFHGAPLTVA TTGPSVYYSQ SPAYNSQYLL RPAANVTPTK GSSNTEFKST KEGFSIPVSA DGFKFGISEP GNQEKESEKP LENDTGFQAQ DISGQKNGRG VIFGQTSSTF TFADVAKSTS GEGFQFGKKD PNFKGFSGAG EKLFSSQCGK MANKANTSGD FEKDDDAYKT EDSDDIHFEP VVQMPEKVEL VIGEEGEKVL YSQGVKLFRF DAEVRQWKER GLGNLKILKN EVNGKPRMLM RREQVLKVCA NHWITTTMNL KPLSGSDRAW MWSASDFSDG DAKLERLAAK FKTPELAEEF KQKFEECQQL LLDIPLQTPH KLVDTGRAAK LIQRAEEMKS GLKDFKTFLT NDQTKVTEEE NKGSGTGAAG ASDTTIKPNP ENTGPTLEWD NCDLREDALD DSVSSSSVHA SPLASSPVRK NLFHFGESTT GSNFSFKSAL SPSKSPAKLN QSGTSVGTDE ESDVTQEEER DGQYFEPVVP LPDLVEVSSG EENEKVVFSH RAELYRYDKD VGQWKERGIG DIKILQNYDN KQVRIVMRRD QVLKLCANHT ITPDMSLQNM KGTERVWVWT ACDFADGERK VEHLAVRFKL QDVADSFKKI FDEAKTAQEK DSLITPHVSR SSTPRESPCG KIAVAVLEET TRERTDVIQG DDVADAASEV EVSSTSETTT KAVVSPPKFV FGSESVKRIF SSEKSKPFAF GNSSATGSLF GFSFNASLKS NNSETSSVAQ SGSESKVEPK KCELSKNSDI EQSSDSKVKN LSASFPMEES SINYTFKTPE KEPPLWHAEF TKEELVQKLS STTKSADHLN GLLREAEATS AVLMEQIKLL KSEIRRLERN QEQEESAANV EHLKNVLLQF IFLKPGSERE RLLPVINTML QLSPEEKGKL AAVAQGEE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with RGPD4?

The strongest Open Targets associations for RGPD4 are isolated congenital hypogonadotropic hypogonadism, Testicular regression syndrome, 46,XY complete gonadal dysgenesis, 46,XX testicular disorder of sex development and systemic scleroderma.

How long is the RGPD4 protein?

The Homo sapiens RGPD4 protein (UniProt Q7Z3J3) is 1758 amino acids long.

Browse: Targets: R · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q7Z3J3 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q7Z3J3 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

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