Pogo transposable element with ZNF domain (POGZ)

Homo sapiens — UniProt Q7Z3K3

Gene: POGZHomo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Pogo transposable element with ZNF domain (POGZ) is a protein from Homo sapiens identified by UniProt accession Q7Z3K3, 1410 residues long. MolForge cross-references it against 0 known binders and 97 disease associations.

UniProt accession: Q7Z3K3; gene symbol POGZ.
Organism: Homo sapiens.
Length: 1410 amino acids.
Top disease associations (Open Targets): intellectual disability-microcephaly-strabismus-behavioral abnormalities syndrome, Intellectual disability and white-sutton syndrome.
3D structure: AlphaFold model available.

Target properties

Protein name	Pogo transposable element with ZNF domain
UniProt accession	Q7Z3K3
Gene	POGZ
Organism	Homo sapiens
Length	1410 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (97)

Diseases linked to this target (Open Targets).

intellectual disability-microcephaly-strabismus-behavioral abnormalities syndrome · score 0.71
Intellectual disability · score 0.67
white-sutton syndrome · score 0.61
autism spectrum disorder · score 0.56
genetic disorder · score 0.54
neurodegenerative disease · score 0.52
Neurodevelopmental disorder · score 0.49
Microcephaly · score 0.34
Global developmental delay · score 0.34
Strabismus · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q7Z3K3-F1	alphafold	PREDICTED	57.29	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z3K3.

Amino-acid sequence (1410 residues)

MADTDLFMEC EEEELEPWQK ISDVIEDSVV EDYNSVDKTT TVSVSQQPVS APVPIAAHAS VAGHLSTSTT VSSSGAQNSD STKKTLVTLI ANNNAGNPLV QQGGQPLILT QNPAPGLGTM VTQPVLRPVQ VMQNANHVTS SPVASQPIFI TTQGFPVRNV RPVQNAMNQV GIVLNVQQGQ TVRPITLVPA PGTQFVKPTV GVPQVFSQMT PVRPGSTMPV RPTTNTFTTV IPATLTIRST VPQSQSQQTK STPSTSTTPT ATQPTSLGQL AVQSPGQSNQ TTNPKLAPSF PSPPAVSIAS FVTVKRPGVT GENSNEVAKL VNTLNTIPSL GQSPGPVVVS NNSSAHGSQR TSGPESSMKV TSSIPVFDLQ DGGRKICPRC NAQFRVTEAL RGHMCYCCPE MVEYQKKGKS LDSEPSVPSA AKPPSPEKTA PVASTPSSTP IPALSPPTKV PEPNENVGDA VQTKLIMLVD DFYYGRDGGK VAQLTNFPKV ATSFRCPHCT KRLKNNIRFM NHMKHHVELD QQNGEVDGHT ICQHCYRQFS TPFQLQCHLE NVHSPYESTT KCKICEWAFE SEPLFLQHMK DTHKPGEMPY VCQVCQYRSS LYSEVDVHFR MIHEDTRHLL CPYCLKVFKN GNAFQQHYMR HQKRNVYHCN KCRLQFLFAK DKIEHKLQHH KTFRKPKQLE GLKPGTKVTI RASRGQPRTV PVSSNDTPPS ALQEAAPLTS SMDPLPVFLY PPVQRSIQKR AVRKMSVMGR QTCLECSFEI PDFPNHFPTY VHCSLCRYST CCSRAYANHM INNHVPRKSP KYLALFKNSV SGIKLACTSC TFVTSVGDAM AKHLVFNPSH RSSSILPRGL TWIAHSRHGQ TRDRVHDRNV KNMYPPPSFP TNKAATVKSA GATPAEPEEL LTPLAPALPS PASTATPPPT PTHPQALALP PLATEGAECL NVDDQDEGSP VTQEPELASG GGGSGGVGKK EQLSVKKLRV VLFALCCNTE QAAEHFRNPQ RRIRRWLRRF QASQGENLEG KYLSFEAEEK LAEWVLTQRE QQLPVNEETL FQKATKIGRS LEGGFKISYE WAVRFMLRHH LTPHARRAVA HTLPKDVAEN AGLFIDFVQR QIHNQDLPLS MIVAIDEISL FLDTEVLSSD DRKENALQTV GTGEPWCDVV LAILADGTVL PTLVFYRGQM DQPANMPDSI LLEAKESGYS DDEIMELWST RVWQKHTACQ RSKGMLVMDC HRTHLSEEVL AMLSASSTLP AVVPAGCSSK IQPLDVCIKR TVKNFLHKKW KEQAREMADT ACDSDVLLQL VLVWLGEVLG VIGDCPELVQ RSFLVASVLP GPDGNINSPT RNADMQEELI ASLEEQLKLS GEHSESSTPR PRSSPEETIE PESLHQLFEG ESETESFYGF EEADLDLMEI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with POGZ?

The strongest Open Targets associations for POGZ are intellectual disability-microcephaly-strabismus-behavioral abnormalities syndrome, Intellectual disability, white-sutton syndrome, autism spectrum disorder and genetic disorder.

How long is the POGZ protein?

The Homo sapiens POGZ protein (UniProt Q7Z3K3) is 1410 amino acids long.

Browse: Targets: P · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q7Z3K3 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q7Z3K3 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

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